Research Associate in Bioinformatics – Cancer & Genomic Sciences – 97562 – Grade 6-(21000107)
Institute of Cancer & Genomic Sciences
Location: University of Birmingham, Edgbaston, Birmingham UK
Full time starting salary is normally in the range £27,511 to £30,046, with potential progression once in post to £33,797.
Full Time FTC up to 2 years
Closing date extended to 1 September 2021 (if sufficient applications are received the advert may close early)
This is an exciting and unique opportunity for an ambitious graduate data scientist with the ability and confidence to perform the analysis and integration of cancer genomic sequencing data. The post holder will be a bioinformatician or computational biologist with a background in Next Generation Sequencing analysis and pipeline creation.
Summary of Role
We are looking to recruit an enthusiastic research bioinformatician who will lead the development of novel approaches to functional genomics of aneuploidy of GI cancers.
Oesophageal Cancer is a highly lethal tumour. Its progression is driven by large-scale genomic events leading to aneuploidy. We are carrying out a project to carry out comprehensive molecular characterisation of aneuploidy in Oesophageal Adenocarcinomas in order to inform rational stratification and drug selection in patients. For this, we would like to appoint a bioinformatician experienced in cancer datasets as soon as possible. The project will involve multi-modal analysis of DNAseq, RNAseq and long read sequencing (Nanopore) technologies. The lab is a full member of the 100,000 Genomes project for Pan-cancer and UpperGI GeCIPs and thus has access to datasets from across the entire 100,000 Genomes project.
The project will be based within the Cancer Structural Variation and Aneuploidy Research Lab (PI Dr Gianmarco Contino), based in the Institute of Cancer & Genomic Sciences. This laboratory specialises in the investigation of aneuploidy in gastrointestinal cancer utilizing approaches of functional genomics. The lab consists of 7 members, and is a mix of research associates, clinical research fellows, PhD and Master students. The laboratory is based within the IBR building of the Medical School. The laboratory has access to the University HPC cloud facility, with > 1000 cores and > 2PB of online disk storage. The candidate will be also affiliated with the Center for Computational Biology at the University of Birmingham. The laboratory PI, Gianmarco Contino is a Senior Clinical Lecturer in Cancer Genomic medicine and member or chair of several international consortia such as OCCAMS, ICGC, GEL and EORTC.
• Create pipelines to process, analyse, and integrate multiple (epi)genomics/transcriptomics sequencing and array-based experiments
• Apply cutting edge machine learning methods to integrate multi-omics data with real-world clinical outcomes data in consultation with clinical experts
• Contribute to Centre/Institute research-related activities and research-related administration
• Contribute to enterprise, business development and/or public engagement activities of manifest benefit to the College and the University, often under supervision of a project leader
• Collect research data; this may be through a variety of research methods, such as scientific experimentation, literature reviews, and research interviews
• Present research outputs, including drafting academic publications or parts thereof, for example at seminars and as posters
• Provide guidance, as required, to support staff and any students who may be assisting with the research
• Deal with problems that may affect the achievement of research objectives and deadlines
• Carry out administrative tasks related directly to the delivery of the research
• Promotes equality and values diversity acting as a role model and fostering an inclusive working culture.
• Degree or equivalent in relevant subject area (Bioinformatics, Mathematics, Statistics, Computer Science)
• Practical experience of applying the relevant skills and techniques
o Proficiency in modern languages (e.g. Perl, Python, R),
o Experience in variant detection and characterization (WGS/WES),
o Experience creating reproducible bioinformatics pipelines
o Experience with machine learning packages and analysis
o Experience with the Genomics England Research Environment
o Experience with Cancer Genomics and Illumina pipeline
• Ability to analyse information and communicate effectively
o Experience of R ggplot
o Track record of presentations
• Ability to access and organise resources successfully
o Experience of managing scientific projects
o Portfolio of personal programming projects
• Knowledge of the protected characteristics of the Equality Act 2010, and how to actively ensure in day to day activity in own area that those with protected characteristics are treated equally and fairly.
Valuing excellence, sustaining investment
We value diversity and inclusion at the University of Birmingham and welcome applications from all sections of the community and are open to discussions around all forms of flexible working
:Cancer and Genomic Sciences
:29.06.2021, 7:00:00 PMGrade (for job description):Grade 6
Salary (Pay Basis)
Advert Close Date
:01.09.2021, 6:59:00 PMFixed Term Contract End Date31.08.2023
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