A 3-year PhD Studentship funded by a Cystic Fibrosis Strategic Research Centre (SRC) grant, is available within the Genetics and Genomic Medicine Research and Teaching Department, Great Ormond Street UCL Institute of Child Health under the supervision of Professor Steve Hart on a project focusing on delivery of CRISPR.SRC020 involves a collaboration between leading research groups working in cystic fibrosis, gene editing and stem cell research based and funds three PhD studentships in all, with, in addition to UCL, Professor Deborah Baines () at St George’s University London (epithelial physiology), and another with Dr Patrick Harrison () at University College Cork (gene editing strategies). In addition, a postdoc position will be available with Dr Paola Bonfanti () at The Francis Crick Institute (engraftment of lung stem cells). Please contact PIs directly for more information on these positions.The collaboration also involves Prof Isabelle Sermet–Gaudelus at the Institut Necker Enfants Malades/INSERM in Paris.The studentships will commence in October 2021.Studentship DescriptionThe purpose of the proposed investigationCystic fibrosis is a genetic disease caused by mutations in the CFTR gene that affects several organs but in particular the lung. Airways become blocked by a thick sticky mucus making breathing difficult and patients develop chronic bacterial infections that cause progressive damage to the lungs. The aims of the proposed research are to develop gene editing technologies as a therapy for cystic fibrosis. CRISPR-mediated gene editing has emerged in recent years and its therapeutic potential has caused great excitement with the precise and permanent correction of genetic mutations. This project is focused on the challenge of bringing CRISPR gene editing to CF patients by identifying the most effective gene editing strategies and methods of delivery. The project will exploit the latest in nanotechnologies, and advanced cell culture models and in vivo models to translate those findings to an effective method of delivery and therapy.Person SpecificationApplicants should have, or expect to receive an upper second-class Bachelor’s degree and a Master’s degree (or equivalent work experience) in Molecular/Cell Biology, Genetics, or a similar discipline, or an overseas qualification of an equivalent standard.Applicants must have basic laboratory skills in molecular biology. It is particularly important, due to the highly collaborative nature of the project, that applicants have the ability to communicate data and ideas effectively in both verbal and written forms. Applicants should be willing to travel to attend meetings with collaborators and may be required to spend some time in other laboratories in the UK, Ireland or France for training. Prior experience in the field of gene therapy or molecular genetics will be an advantage.EligibilityApplicants should be ordinarily resident in the UK or EU. This studentship covers the cost of tuition fees based on the UK (Home) rate.NB: You will be asked about your likely fee status at the interview so we would advise you to contact the for advice should you be unsure whether or not you meet the eligibility criteria for Home fee status. Further information on Brexit and the definitions for fee status assessment can be found on the and also the (Higher Education: Definitions for fee status assessment).The student will receive a starting stipend of £22,278 per annum as well as the cost of tuition fees at the UK (Home) rate.To apply, please send a current CV including the contact details of two professional referees as well as a cover letter to Amy Pu (). Enquires can be made to Professor Stephen Hart (; 020 7905 2228).Contact nameAmy PuContact details UCL Taking Action for Equality Closing Date9 Aug 2021Interview dateTBC (aiming for August – September 2021)Studentship Start DateOctober 2021

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